Turchin Il'ya Viktorovich

Tissue optics. Development of optical devices for biomedical diagnostics:

• fluorescence imaging of laboratory animals - epi-illumination and projection imaging, diffuse fluorescence tomography, time-resolved imaging;
• fluorescence diagnostics and monitoring during photodynamic therapy;
• fluorescence angiography of blood and lymphatic vessels;
• diffuse optical spectroscopy for diagnostics of breast diseases and reconstructive surgery;
• optoacoustic tomography and microscopy of biotissues;
• diagnostics of plants based on reflective indices and the PAM method

• 2007 – graduate of the International Graduate Summer School Biophotonics '07 (Sweden)
• 2006 – PhD, Physics
• 2000 – 2003: postgraduate student at the IAP RAS
• 2000 – MS degree, Physics at the Advanced School of General at Applied Physics, Nizhny Novgorod State University
• 1994–2000: Student at the Advanced School of General at Applied Physics, Nizhny Novgorod State University

• 2018-present: introduction to the specialty Radiophysics Faculty and Higher School of General and Physics at the Nizhny Novgorod State University
• 2009: a course of lectures "Optical methods for biomedical diagnostics" for the graduates of the Radiophysics Faculty at the Nizhny Novgorod State University has been developed.
• 2009-2013: assistant professor in Nizhny Novgorod State University
• 2012 - 2017: lectures "Optical bioimaging" for students of the Nizhny Novgorod State Medical Academy
• 2017-2019: lectures at radiophysical faculty of NNSU

• 2013 - present: Head of the Department for radiophysical methods in medicine at the IAP RAS
• 2007 - present: Head of Biophotonics Laboratory at the IAP RAS
• 2011 - 2014: Researcher at the Nizhny Novgorod State Medical Academy
• 1998-2006: Researcher at the IAP RAS

Organization of scientific conferences

• 2023 – Chair of the Russian conference Current Trends in Biophotonics (Nizhny Novgorod, Russia)
• 2019 – Program committee member of the Frontiers in Optics conference (Washington, District of Columbia, USA)
• 2019 - Chair of the International Symposium Topical problems of Biophotonics
• 2015, 2017 - Conference Chair of the Optical Bioimaging Conference at the Topical problems of Biophotonics
• 2007,2009,2011,2013 – Scientific Secretary of the Optical Bioimaging Conference at the International Symposium Topical Problems of Biophotonics (Nizhny Novgorod, Russia)
• 2012,2014 – Program committee member of the OSA Biomedical Topical Meeting (Miami Beach, USA)
• 2012 - Program committee member of the upcoming ACP2012 (Guangzhou, China)

HONORS AND AWARDS

• 2024 – A.I. Kozhevnikov badge “For contribution to the development of oncology service in the Nizhny Novgorod region” (as part of the IAP RAS team)
• 2024 – “300th Anniversary of the Russian Academy of Sciences” medal
• 2023 – Diploma of the Scientific Commission on Photonics of the Physical Sciences Division of the Russian Academy of Sciences recognizes the most important results of 2023 “Broadband optical diffusion spectroscopy of biological tissues with a self-calibrating contact fiber-optic probe and its application in transplantology”. Authors: Turchin I.V., Kirillin M.Yu., Kostyuk A.B., Kurakina D.A., Orlova A.G., Perekatova V.V., Khilov A.V., Sergeeva E.A. (IAP RAS), Beschatnov V.V., Ryabkov M.G. (PIMU)
• 2022 – Diploma of the Scientific Commission on Photonics of the Physical Sciences Division of the Russian Academy of Sciences recognizes the most important results of 2022 "Optoacoustic angiography and diffuse optical spectroscopy for experimental oncology" Authors: Orlova A.G., Akhmedzhanova K.G., Kurnikov A.A., Glyavina A.M., Perekatova V.V., Khilov A.V., Kovalchuk A.V., Kazakov V.V., Turchin I.V., Subochev P.V. (IAP RAS); Maslennikova A.V., Skamnitsky D.V. (State Budgetary Healthcare Institution of the Nizhny Novgorod Region "NOKOD"); Khochenkov D.A., Khochenkova Yu.A. (N.N. Blokhin National Medical Research Center of Oncology, Moscow); Ryazansky D.A. (ETH Zurich, Switzerland)
• 2022 – First-degree Diploma in the nomination “Best Invention of the Year in Medicine and Pharmaceutics” for patent RU No. 2760989 “Method for predicting the risk of free autodermal transplant necrosis” (intellectual property competition for the I.P. Kulibin Nizhny Novgorod Region)
• 2017 – Award of the Russian Academy of Sciences
• 2017 – Diploma of II degree in the nomination "The Best Invention of the Year in the Field of Electronics and Instrument Engineering" for patent No. 2596869 "Device for fluorescent diagnostics and monitoring of photodynamic therapy" (IP Kulibin XI competition of intellectual property for the award of the Nizhniy Novgorod region)
• 2014 - Diploma of II degree in the nomination "The Best Invention of the Year in the Nizhny Novgorod Region in the Field of Electronics and Instrument Engineering" for patent No. 2515203 "A device for obtaining tomographic fluorescent images" (IP Kulibin IX competition of intellectual property for the award of the Nizhniy Novgorod region)
• 2014 - Diploma of III degree in the nomination "The best utility model of the year in the Nizhny Novgorod region in the field of medicine" for patent No. 137459 "Optoacoustic microscope for functional bioimaging" (IP Kulibin IX competition of intellectual property for the award of the Nizhniy Novgorod region)
• 2013 – Silver medal for invention "Diffuse fluorescence tomography setup for biomedical research", 24-th International Invention, Innovation & Technology Exibition ITEX 2013, Malaysia, Kuala Lumpur, 9-11 May 2013 (authors: Turchin Ilya, Kleshnin Mikhail, Kamensky Vladislav, Fiks Ilya)
• 2012 - Award of the Nizhny Novgorod Ministry of Industry and Innovations
• 2009 – Gold medal of the American-Russian Business Union (ARBU) for the innovation "Diffusion Optical Tomography"
• 2008 – Gold medal at the Belgian and International Trade Fair for Technological Innovations for the innovation "Polarization optical spectrometer"

MANAGING OF SCIENTIFIC PROJECTS

• 2014-present: project "Acoustic and optical methods for studying the structure and dynamics of physiological processes in biological tissues" within the framework of the state assignment of the IAP RAS
• 2020-2021: Project No. 61811 of the Foundation for Assistance to Small Innovative Enterprises for R & D "Development of prototypes of a mobile fluorescence visualizer"
• 2017-2020: PI of the Russian team (project RFBR #17-54-33043-онко-а) of the U.S.–Russia Bilateral Collaborative Research Partnerships on Cancer Grant (NIH-RFBR) “Optical imaging guided resection and photodynamic therapy of glioma with targeted photoactivable agents”
• 2014-2018: grant of the Russian Science Foundation «Development of optoacoustic method for biological tissue visualization using multi-element antenna» (##14-15-00709,14-15-00709-П)
• 2014-2015: project: «Development of the device for control of the photosensitizer accumulation and monitoring of the PDT process» in the frames of the Federal Targeted Program «Research and development on priority directions of scientific-technological complex of Russia in 2014 - 2020 years» (state contract # 14.604.21.0027 from 17.06.2014)
• 2013-2015: grant of the Russian Foundation for Basic Research «Development of the whole-body fluorescence lifetime imaging methods for visualization of molecular processes at the organism level» (project # 13-02-01289-а)
• 2013-2015: grant of the Russian Foundation for Basic Research: «Simultaneous ultrasound and spectral photoacoustic microscopy for functional and structural diagnostics of biotissues» (project # 13-04-40306)
• 2013: project "Development of the photoacoustics functional imaging methods" in the frames of the Federal Targeted Program “R&D in Priority Fields of the S&T Complex of Russia (2007-2013)” (state contract # 14.512.11.0053)
• 2011-2012: project "Development of the fluorescence and bioluminescence small-animal molecular in vivo imaging" in the frames of the Federal Targeted Program “R&D in Priority Fields of the S&T Complex of Russia (2007-2013)” (state contract # 16.512.11.2140)
• 2011-2012: grant of the Russian President for supporting of young Russian scientists: "Developments of the in vivo fluorescence imaging methods for the experimental oncology investigations" (project # 16.120.11.1909-МК)
• 2010-2012: grant of the Russian Foundation for Basic Research: «Developments of the Fluorescence Diffuse Tomography» (project # 10-02-01109-а)
• 2007-2009: grant of the Russian Foundation for Basic Research: «Fluorescence Diffuse Tomography»

Selected publications 2019-2024

1. Sergeeva E., Kurakina D., Turchin I., Kirillin M. A refined analytical model for reconstruction problems in diffuse reflectance spectroscopy // Journal of Innovative Optical Health Sciences. ‒ 2024. ‒ T. 17, № 5.
2. Druzhkova I., Bylinskaya K., Plekhanov A., Kostyuk A., Kirillin M., Perekatova V., Khilov A., Orlova A., Polozova A., Komarova A., Lisitsa U., Sirotkina M., Shirmanova M., Turchin I. Effects of FOLFOX Chemotherapy on Tumor Oxygenation and Perfused Vasculature: An In Vivo Study by Optical Techniques // Journal of Biophotonics. ‒ 2024. ‒ C. e202400339.
3. Turchin I., Beschastnov V., Peretyagin P., Perekatova V., Kostyuk A., Orlova A., Koloshein N., Khilov A., Sergeeva E., Kirillin M., Ryabkov M. Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound // Biomedicines. ‒ 2023. ‒ T. 11, № 2. ‒ C. 351.
4. Perekatova V., Kostyuk A., Kirillin M., Sergeeva E., Kurakina D., Shemagina O., Orlova A., Khilov A., Turchin I. VIS-NIR diffuse reflectance spectroscopy system with self-calibrating fiber-optic probe: study of perturbation resistance // Diagnostics. ‒ 2023. ‒ T. 13, № 3. ‒ C. 457.
5. Pavlov M. V., Bavrina A. P., Plekhanov V. I., Golubyatnikov G. Y., Orlova A. G., Subochev P. V., Davydova D. A., Turchin I. V., Maslennikova A. V. Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy // Breast Cancer Research: BCR. ‒ 2023. ‒ T. 25, № 1. ‒ C. 16-16.
6. Orlova A., Pavlova K., Kurnikov A., Maslennikova A., Myagcheva M., Zakharov E., Skamnitskiy D., Perekatova V., Khilov A., Kovalchuk A., Moiseev A., Turchin I., Razansky D., Subochev P. Noninvasive optoacoustic microangiography reveals dose and size dependency of radiation-induced deep tumor vasculature remodeling // Neoplasia. ‒ 2022. ‒ T. 26. ‒ C. 100778.
7. Kurakina D., Perekatova V., Sergeeva E., Kostyuk A., Turchin I., Kirillin M. Probing depth in diffuse reflectance spectroscopy of biotissues: a Monte Carlo study // Laser Physics Letters. ‒ 2022. ‒ T. 19, № 3. ‒ C. 035602.
8. Akhmedzhanova K., Kurnikov A., Khochenkov D., Khochenkova Y. A., Glyavina A., Kazakov V., Yudintsev A., Maslennikova A., Turchin I., Subochev P. In vivo monitoring of vascularization and oxygenation of tumor xenografts using optoacoustic microscopy and diffuse optical spectroscopy // Biomedical Optics Express. ‒ 2022. ‒ T. 13, № 11. ‒ C. 5695-5708.
9. Turchin I., Bano S., Kirillin M., Orlova A., Perekatova V., Plekhanov V., Sergeeva E., Kurakina D., Khilov A., Kurnikov A., Subochev P., Shirmanova M., Komarova A., Yuzhakova D., Gavrina A., Mallidi S., Hasan T. Combined fluorescence and optoacoustic imaging for monitoring treatments against ct26 tumors with photoactivatable liposomes // Cancers. ‒ 2021. ‒ T. 14, № 1. ‒ C. 197.
10. Sukhov V., Sukhova E., Khlopkov A., Yudina L., Ryabkova A., Telnykh A., Sergeeva E., Vodeneev V., Turchin I. Proximal imaging of changes in photochemical reflectance index in leaves based on using pulses of green-yellow light // Remote Sensing. ‒ 2021. ‒ T. 13, № 9. ‒ C. 1762.
11. Perekatova V., Kirillin M., Subochev P., Kurnikov A., Khilov A., Orlova A., Yuzhakova D., Turchin I. Quantification of microvasculature parameters based on optoacoustic angiography data // Laser Physics Letters. ‒ 2021. ‒ T. 18, № 3. ‒ C. 035602.
12. Orlova A., Perevalova Y., Pavlova K., Orlinskaya N., Khilov A., Kurakina D., Shakhova M., Kleshnin M., Sergeeva E., Turchin I., Kirillin M. Diffuse optical spectroscopy monitoring of experimental tumor oxygenation after red and blue light photodynamic therapy // Photonics. ‒ T. 9 ‒MDPI, 2021. ‒ C. 19.
13. Kirillin M., Khilov A., Kurakina D., Orlova A., Perekatova V., Shishkova V., Malygina A., Mironycheva A., Shlivko I., Gamayunov S., Turchin I., Sergeeva E. Dual-wavelength fluorescence monitoring of photodynamic therapy: from analytical models to clinical studies // Cancers. ‒ 2021. ‒ T. 13, № 22. ‒ C. 5807.
14. Fiks I. y. I., Turchin I. V. Reconstruction of fluorophore concentration distribution in diffuse fluorescence tomography based on Tikhonov regularisation and nonnegativity condition // Quantum Electronics. ‒ 2021. ‒ T. 51, № 5. ‒ C. 400.
15. Kurakina D., Khilov A., Shakhova M., Orlinskaya N., Sergeeva E., Meller A., Turchin I., Kirillin M. Comparative analysis of single-and dual-wavelength photodynamic therapy regimes with chlorin-based photosensitizers: animal study // Journal of Biomedical Optics. ‒ 2020. ‒ T. 25, № 6. ‒ C. 063804-063804.
16. Perekatova V., Subochev P., Kirillin M. Y., Sergeeva E., Kurakina D., Orlova A., Postnikova A., Turchin I. Quantitative techniques for extraction of blood oxygenation from multispectral optoacoustic measurements // Laser Physics Letters. ‒ 2019. ‒ T. 16, № 11. ‒ C. 116201.
17. Orlova A., Sirotkina M., Smolina E., Elagin V., Kovalchuk A., Turchin I., Subochev P. Raster-scan optoacoustic angiography of blood vessel development in colon cancer models // Photoacoustics. ‒ 2019. ‒ T. 13. ‒ C. 25-32.
18. Kurakina D., Kirillin M., Perekatova V., Plekhanov V., Orlova A., Sergeeva E., Khilov A., Nerush A., Subochev P., Mallidi S., Turchin I., Hasan T. Towards bimodal optical monitoring of photodynamic therapy with targeted nanoconstructs: a phantom study // Applied Sciences. ‒ 2019. ‒ T. 9, № 9. ‒ C. 1918.
19. Kleshnin M. S., Turchin I. V. Evaluation of oxygenation in the surface layers of biological tissues based on diffuse optical spectroscopy with automated calibration of measurements // Quantum Electronics. ‒ 2019. ‒ T. 49, № 7. ‒ C. 628.